Supporting Studies for Ingredients in Blood Support

SILENA HERON, N.D., and ERIC YARNELL, N.D. "The Safety of Low-Dose Larrea tridentata (DC) Coville (Creosote Bush or Chaparral): A Retrospective Clinical Study." THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE. Volume 7, Number 2, 2001, pp. 175–185.

Lü JM, Nurko J, Weakley SM, Jiang J, et al. "Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update." Med Sci Monit. 2010 May;16(5):RA93-100.

Hwu JR1, Hsu CI, Hsu MH, Liang YC, Huang RC, Lee YC. "Glycosylated nordihydroguaiaretic acids as anti-cancer agents." Bioorg Med Chem Lett. 2011 Jan 1;21(1):380-2.

Hsu MH1, Wu SC, Pao KC, Unlu I, et al. "Hepatocellular carcinoma targeting agents: conjugates of nitroimidazoles with trimethyl nordihydroguaiaretic Acid." ChemMedChem. 2014 May;9(5):1030-7.

Zhang Y1, Xu S, Lin J, Yao G, Han Z, Liang B, et al. "mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo." Breast Cancer Res Treat. 2012 Nov;136(2):379-88.

Ryan CJ1, Zavodovskaya M, Youngren JF, Campbell M, Diamond M, Jones J, Shiry L, et al. "Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells." Prostate. 2008 Aug 1;68(11):1232-40.

Chen H1, Teng L, Li JN, Park R, Mold DE, et al. "Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA."J Med Chem. 1998 Jul 30;41(16):3001-7.

Zhao J1, Zhao Y, Chen W, Li YM, Bian XW. "The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8." Anticancer Drugs. 2008 Aug;19(7):713-9.

Gao P1, Zhai F, Guan L, Zheng J. "Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21."Oncol Lett. 2011 Jan;2(1):123-128.

Peterson G1, Barnes S. "Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation." Prostate. 1993;22(4):335-45.

Lai K. Leung, Ho Yee Chan, Huan Wang. "The red clover (Trifolium pratense) isoflavone biochanin A modulates the biotransformation pathways of 7,12-dimethylbenz[a]anthracene." British Journal of Nutrition / Volume 90 / Issue 01 / July 2003, pp 87-92.

Stephens FO. "Phytoestrogens and prostate cancer: possible preventive role." MJA. 1997;167:138-140.

Jarred RA, Keikha M, Dowling C, et al. "Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones." Cancer Epidemiol Biomarkers Prev. 2002;11:1689-1696.

Stephens F. O. “Phytoestrogens and prostate cancer: possible preventive role.” Med. J. Aust., 167: 138-140, 1997.

Zhao F, Wang L, Liu K. "In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway." J Ethnopharmacol. 2009 Apr 21;122(3):457-62.

Lin SC, et al. "Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride." J Biomed Sci 2002 Sep-Oct;9(5):401-9.

Lu LC, Zhou W, Li ZH, et al. "Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats." Planta Med. 2012 Aug;78(12):1317-23.

Hirose M, Yamaguchi T, Lin C, et al. "Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats." Cancer Lett. 2000 Jul 3;155(1):79-88.

Huang K1, Li LA, Meng YG, You YQ, Fu XY, Song L. "Arctigenin Promotes Apoptosis in Ovarian Cancer Cells via the iNOS/NO/STAT3/Survivin Signalling." Basic Clin Pharmacol Toxicol. 2014 May 19.

Susanti S1, Iwasaki H, Inafuku M, Taira N, Oku H. "Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines." Phytomedicine. 2013 Dec 15;21(1):39-46.

Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu YL. "Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation." Free Radic Biol Med. 2014 Feb;67:159-70.

Ek O, Waurzyniak B, Myers DE, Uckun FM. "Antitumor activity of TP3(anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of human osteosarcoma." Clin Cancer Res. 1998 Jul;4(7):1641-7.

Anderson PM, Meyers DE, Hasz DE, Covalcuic K, et al. "In vitro and in vivo cytotoxicity of an anti-osteosarcoma immunotoxin containing pokeweed antiviral protein." Cancer Res. 55: 1321-7, 1995.

Qi L, Nett TM, Allen MC, et al. "Binding and cytotoxicity of conjugated and recombinant fusion proteins targeted to the gonadotropin-releasing hormone receptor." Cancer Res. 2004;64:2090-2095.

Wimer BM, Mann PL. "Mitogen immunotherapy for HIV infections exemplified by phytohemagglutinin and pokeweed mitogen." Cancer Biother Radiopharm. 2001;15:629--44.

Fatih M Uckun, Larisa Rustamova, Alexei O Vassilev, et al. "CNS activity of Pokeweed Anti-viral Protein (PAP) in mice infected with Lymphocytic Choriomeningitis Virus (LCMV)." BMC Infect Dis. 2005; 5: 9.

Wegiera M1, Smolarz HD, Bogucka-Kocka A. "Rumex L. species induce apoptosis in 1301, EOL-1 and H-9 cell lines." Acta Pol Pharm. 2012 May-Jun;69(3):487-99.

Rostock M, Huber R, Greiner T, Fritz P, Scheer R, Schueler J, Fiebig HH. "Anticancer activity of a lectin-rich mistletoe extract injected intratumorally into human pancreatic cancer xenografts." Anticancer Res. 2005 May-Jun;25(3B):1969-75.

"Mistletoe Extracts (PDQ®) - Human Clinical Trials." National Cancer Institute. (Accessed 31 May 2014.)

Tröger W, Zdrale Z, Tišma N, Matijaševic M. "Additional Therapy with a Mistletoe Product during Adjuvant Chemotherapy of Breast Cancer Patients Improves Quality of Life: An Open Randomized Clinical Pilot Trial." Evid Based Complement Alternat Med. 2014;2014:430518.

Adaramoye O, Amanlou M, Habibi-Rezaei M, Pasalar P, Ali MM. "Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats." Asian Pac J Trop Med. 2012 Jun;5(6):427-33.

Gray AM, Flatt PR. "Insulin-secreting activity of the traditional antidiabetic plant Viscum album (mistletoe)." J Endocrinol. 1999 Mar;160(3):409-14.

Stephen S. Leonarda, Deborah Keilb, Tracey Mehlmanb, et al. "Essiac tea: Scavenging of reactive oxygen species and effects on DNA damage." Journal of Ethnopharmacology Volume 103, Issue 2, 16 January 2006, Pages 288--296.

Soroush Sardari, Mohammad Ali Shokrgozar, Ghazaleh Ghavami. "Cheminformatics based selection and cytotoxic effects of herbal extracts." Toxicology in Vitro, Volume 23, Issue 7, October 2009, Pages 1412-1421.

"What is the mechanism by which Cat's claw (Uncaria tomentosa) can increase the blood concentrations of the protease inhibitors, atazanavir (Reyataz), ritonavir (Norvir), saquinavir, (Invirase) used for the treatment of HIV?" Pharmacology Weekly. (Accessed 1 June 1014.)

Kaiser S, Dietrich F, de Resende PE, Verza SG, Moraes RC, et al. "Cat's claw oxindole alkaloid isomerization induced by cell incubation and cytotoxic activity against T24 and RT4 human bladder cancer cell lines." Planta Med. 2013 Oct;79(15):1413-20.

Dreifuss AA, Bastos-Pereira AL, Fabossi IA, Lívero FA, et al. "Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity." PLoS ONE 8(2): e54618.

Rinner B, Li ZX, Haas H, Siegl V, Sturm S, Stuppner H, Pfragner R. "Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells." Anticancer Res. 2009 Nov;29(11):4519-28.

Pilarski R, Poczekaj-Kostrzewska M, Ciesiolka D, Szyfter K, Gulewicz K. "Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells." Pharmacol Rep. 2007 Sep-Oct;59(5):565-72.

Sun M1, Liu C, Nadiminty N, Lou W, Zhu Y, et al. "Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion." Prostate. 2012 Jan;72(1):82-9.

Malikova J, Zdarilova A, Hlobilkova A. "Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis." Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):5-12.

Haseeb Ahsan, Shannon Reagan-Shaw, Jorien Breur, Nihal Ahmad. "Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins." Cancer Letters Volume 249, Issue 2 , Pages 198-208, 8 May 2007.

Shin Kim, Tae-Jin Lee, Jaechan Leem, Kyeong Sook Choi, Jong-Wook Park, and Taeg Kyu Kwon. "Sanguinarine-induced apoptosis: Generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL." Journal of Cellular Biochemistry Volume 104, Issue 3,  pages 895--907, 1 June 2008.

Kim JB, Yu JH, Ko E et al. "The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest." Phytomedicine 17 (6): 436--40. PMID 19800775.

Lin CC, Lin SY, Chung JG, Lin JP, Chen GW, Kao ST. "Down-regulation of cyclin B1 and up-regulation of Wee1 by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle." Anticancer Research 26 (2A): 1097--104.

Serafim TL, Oliveira PJ, Sardao VA, Perkins E, Parke D, Holy J. "Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line." Cancer Chemotherapy and Pharmacology 61 (6): 1007--18.

Pinto-Garcia L, Efferth T, Torres A, Hoheisel JD, Youns M. "Berberine Inhibits Cell Growth and Mediates Caspase-Independent Cell Death in Human Pancreatic Cancer Cells." Planta Medica 76 (11): 1155--61.

Ho YT, Lu CC, Yang JS et al. (October 2009). "Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells". Anticancer Research 29 (10): 4063--70.

Mantena SK, Sharma SD, Katiyar SK . "Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells." Molecular Cancer Therapeutics 5 (2): 296--308.

Muralimanoharan SB, Kunnumakkara AB, Shylesh B et al. "Butanol fraction containing berberine or related compound from nexrutine inhibits NFkB signaling and induces apoptosis in prostate cancer cells." The Prostate 69 (5): 494--504.

Choi MS, Oh JH, Kim SM et al. "Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells." International Journal of Oncology 34 (5): 1221--30.

Cech NB, Junio HA, Ackermann LW, Kavanaugh JS, Horswill AR. "Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)." Planta Med. 2012 Sep;78(14):1556-61.

Anandakumar P1, Kamaraj S, Jagan S, Ramakrishnan G, Devaki T. "Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice." Int Immunopharmacol. 2013 Oct;17(2):254-9.